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Cellular thiols, hydroquinones and catecholamines can undergo redox reactions and contribute to intracellular ROS production as well
That polarity makes it relatively poor at crossing the lipid-rich stratum corneum
328 ADI-PEG-20, in combination with pemetrexed and cisplatin (ADIPEMCIS), was well tolerated in another phase I study of recurrent high-grade glioma (HGG) (NCT02029690)
doi: 10.3389/fpsyt.2019.01016
O 2 can damage the ironsulfur cluster of proteins
