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10.1146/annurev-publhealth-032013-182351 58 KawaiT.AkiraS
In summary, the role of lactate in macrophages cannot be oversimplified as merely promoting M2. It functions more like a double-edged sword, with its ultimate effect, whether it favors pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes, being tightly regulated by factors such as concentration, duration, cell origin, and the overall tissue microenvironment [108]
Levels turned from very low to very high
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Cell Immunol
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