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I think with all these new modalities, this happened with dry needling and then BFR too had its thing, is it starts to get really popular and you hear a lot of buds around the mechanismic studies, but at the end of the day, the first thing that we have to take care of is safety

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As was noted for DNMT1 and PRMT3, sigmoidal dose-response curves and reliable estimates of IC 50 values could not be obtained since no significant inhibition was observed at the tested NNMT inhibitor concentrations