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This had no impact on the peer review process and the final decision

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Abbreviations ( Cyp11a1 ) Cytochrome P450 family 11 subfamily a polypeptide 1 (ELISA) Enzyme Linked Immunosorbent Assay (FSH) Follicle-Stimulating Hormone (GnRH) Gonadotropin-Releasing Hormone (LC) L-carnitine, (LH): Luteinizing Hormone (MDA) Malondialdehyde (MSG) Monosodium Glutamate (ROS) Reactive Oxygen Species ( Star ) Steroidogenic Acute Regulatory protein (TAC) Total Anti-oxidant Capacity ( Hsd17b3 ) 17-Hydroxysteroid dehydrogenase-3 Authors contributions FK, FG, and MHM did all the experiments, statistical analyses, and figure preparations

Also shown are the adverse clinical outcomes associated with elevated systemic TMAO levels in subjects, and enhanced cardiometabolic phenotypes observed with elevated TMAO levels in animal models (46, 12, 13, 1618)