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The emergence of silicosis is closely linked to the volume, structure and dimensions of the silica particles inhaled [21], whereas IPF is a particular type of interstitial pneumonia that is fibrosing, chronic and progressive, but for which the origin is yet to be determined [22]

[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Jin Z, Mantri Y, Retout M, Cheng Y, Zhou J, Jorns A, Fajtova P, Yim W, Moore C, Xu M, Creyer MN, Borum RM, Zhou J, Wu Z, He T, Penny WF, ODonoghue AJ and Jokerst JV, Angew

doi: 10.1016/j.atherosclerosis.2007.05.012

Cell 83 , 19031920.e12 (2023)

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Mechanism of Action in Humans: While there is substantial preclinical evidence on the molecular mechanisms of bioactive compounds in periodontal tissues, these mechanisms have not been fully validated in human studies