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10.1074/jbc.C100091200 [DOI] [PubMed] [Google Scholar] Dong HH, Zhang ZY, Tang XD, et al

In addition to pyruvate-derived acetyl-CoA, -KG-derived metabolites (e.g., succinate and fumarate) generated via glutaminolysis are considered oncometabolites contributing to tumorigenesis 23

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In several cases, biological effects observed under controlled laboratory conditions have not yet been validated under physiological or clinical settings, highlighting the need for standardized methodologies and long-term intervention studies to confirm efficacy and safety

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307 Important molecules such as RGS4, RGS5, and RGS16, which serve as GTPase-activating proteins for G protein -subunits, are subject to oxygen-dependent breakdown facilitated by the Met-Cys motif