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In a follow-up study, the same group demonstrated that HPDL deficiency induces a lethal form of mitochondrial encephalopathy and, importantly, supplementation with HPDL-derived intermediates (4-HMA or 4-HB) was sufficient to alleviate disease symptoms

Wrote or contributed to the writing of the manuscript: McCoy, Benoist, Wright, Kawas, Bule-Ghogare, Appleyard, Wayman, Harding

This detoxification is believed to improve the overall metabolic function, which can indirectly support weight loss efforts

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