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The best outcome from July's meeting is not simply "yes" or "no" on compounding eligibility it is a regulatory posture that treats these compounds with the scientific rigor their biological plausibility warrants

Introduce gradually over several weeks

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For the experiments shown in Supplementary Figs

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SPMs can decrease levels of pro-inflammatory cytokines, such as IL-1, IL-6, and tumor necrosis factor (TNF)-, through activating their G protein-coupled receptors, thus causing activation of anti-inflammatory transcription factors, such as peroxisome proliferator-activated receptor gamma, and down-regulating intracellular NF-kB signaling pathway (14, 63)