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Langston et al., 1983)

doi: 10.1016/j.neuint.2016.08.005

doi: 10.1111/jcmm.16581 29 ZhangHWangAShenGWangXLiuGYangFet al

Therefore, the success of cereblon-based PROTACs is due to a set of key factors: Firstly, the most commonly used cereblon ligands are IMiDs, as they exhibit highly specific, strong and biophysically validated E3 ligase binding affinity 43

In a previous system of classification that used homology to mammalian PRX isoforms, subfamily AhpC-PRX was subdivided into isoforms PRX1-4 41,45
