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C57BL/6 mouse cortex was collected as non-perfused, with transcardial PBS perfusion, or PBS perfusion + 10U/mL heparin (Sigma-Aldrich, St

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Parallel mechanisms underlying CUD and/or psychosis Recent clinical data now show that individuals with first-episode psychosis with a comorbid CUD have increased neuromelanin (a proxy for dopamine) in psychosis-associated midbrain dopaminergic nuclei, which scaled with CUD severity [6]