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To further improve oxidative stress tolerance, malate biosynthesis pathway was optimized by fine-tuning expression strengths of pyruvate carboxylase and malate dehydrogenase, leading to an enhanced oxidative stress tolerance
Contributes to growth of muscle mass
Each tissue had distinct expression profiles at baseline
Gene ontology enrichment analysis amongst upregulated proteins revealed an overrepresentation of biological processes consistent with EMT in the resistant cell line
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