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we found that ROS accumulated in LCS3-sensitive cancer cell lines H23 and H1650, but not in the resistant HCC2279 cancer cell line or the non-transformed HPL1D lung cell line (Fig

Meanwhile, oxidative stress from excess copper depletes glutathione, catalase, and superoxide dismutase the same antioxidants that protect mitochondria and neurons

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This caspase-3/GSDME axis represents a critical mechanism by which melanoma cells undergo inflammatory cell death in response to therapy, potentially enhancing antitumor immunity (79, 80)

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