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In some ME/CFS patients, such antibodies against neurotransmitter receptors have been identified, such as against the muscarinic M1AChR (504), M3AChR (58, 359, 503), and the adrenergic B2AdR (58, 359, 503)

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doi: 10.1016/j.jhep.2021.05.025 64

NRF2 is considered a central regulator of the cellular responses to changes in redox status but is also an important regulator of an array of processes that includes mitochondrial function, xenobiotic metabolism, carbohydrate, lipid, and iron metabolism, and DNA repair

Studies have indicated that SCFA butyrate can enhance the production of the peptide GLP-1, which plays a crucial role in regulating appetite, food intake, and glucose metabolism by increasing the expression of the insulin gene in intestinal L-cells (Kim et al., 2018