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-syn aggregates also inhibit TFEB nuclear translocation via p38 MAPK, reducing lysosomal biogenesis [166]

10.1104/pp.126.1.445 104 PrasadT

PKC translocates into the mitochondria, where it interacts with ALDH2, increasing its enzyme activity (159)

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, protein kinase C (PKC) and mitogen-activated protein kinase (MAPK)), and metabolic enzymes

The worsening is due to the correlation between reduced melatonin levels and pathologies such as Alzheimers onset, menopause severity, and cardiovascular disorders.7 Melatonin comes from the pineal gland, epitalon is a pineal gland peptide, and clinical research points to a close relationship between the two