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Research has shown that metabolic reprogramming in tumors is involved in the activation and differentiation of hepatic stellate cells (HSCs), such as acidification of the microenvironment inducing HSC activation and differentiation into myofibroblasts in a P-Erk1/2-dependent manner ( Compared with quiescent HSC (qHSC), activated HSC (aHSC) exhibit higher rates of glucose utilization, transport capacity, and glycolytic activity ( Rapid proliferation of liver cancer cells can deplete nutrients in the microenvironment, leading to sustained nutrient deprivation and decreased oxygen levels

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[DOI] [PubMed] [Google Scholar] 39.Pechn I, Minrov H, Babuskov F, Rendekov V, Mizera S, Schramekov E, et al