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When vitamin B12 is deficient essentially all of the folate becomes trapped as the N 5 -methylTHF (5-methylTHF

In a depressed mouse model, this intervention restored hippocampal serotonin levels to normal and reduced the immobility time in the forced swim test (Fung et al., 2017)

doi: 10.1038/s41419-022-04775-z 74 ShenLZhouYHeHChenWLenahanCLiXet al

Conversely, activation of S1PR-2 has been associated with PI3K pathway suppression through an increase in Rho-dependent/PTEN phosphatase activity (254)

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