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Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX), a producer of reactive oxygen species (ROS), acts as a key generator of oxidative stress within pancreatic islet -cells, significantly affecting glucose-induced insulin release and -cell viability in Type 1 and Type 2 diabetes (Shuang et al

Under these circumstances, targeted therapy with glutamine hydrolase holds promise in preclinical models of cardio-cerebral vascular disease (94)

doi: 10.1111/j.1743-6109.2009.01464.x

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and the amelioration of consequently prolonged bleeding) provides ample evidence that the Virchow triad was abolished (Vukojevic et al., 2018)

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