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Intranasal delivery of small extracellular vesicles from specific subpopulation of mesenchymal stem cells mitigates traumatic spinal cord injury

130 TorokZ.HorvathI.GoloubinoffP.KovacsE.GlatzA.BaloghG.et al (1997)

There was a significant main effect of drug (F = 5.60, P = 0.002), a significant main effect of days (F = 3.65, p = 0.0001) and a significant drug x days interaction (F = 2.0, p = 0.001)

Two exercise studies based on blood samples are noteworthy since they tracked intraindividual changes or examined purified exosomes: In the first study, an increase of the pro-inflammatory cytokines IL-6 and IL-1 at 8 h after exercise was predictive of higher post exercise fatigue scores (White et al., 2010) (IL-6 and IL-1 trigger glial reactivity)

Functioning as a neuromodulator, DSIP influences the activity of GABAergic, glutamatergic, and opioid systems, which are integral to sleep, mood regulation, and pain perception ( 2, 6, 7 )

This method bypasses the digestive system, delivering glutathione directly into the bloodstream without degradation