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A fold-change (FC) 1.2 or FC 0.83 in the experimental group compared with that in the control group was considered as up- or downregulation of phospho-specific proteins

Unlike drugs such as phentermine, Cagrilintide is a non-stimulant peptide

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However, it increased heart rate, cardiac output, and induced myocardial degeneration in mice and thus was terminated as a preclinical candidate (Yau et al., 2017)