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Zhao et al., 2018).Particularly worthy of attention is that oxidative stress, as the core regulatory hub of this pathological network, plays a key driving role in SCIRI by mediating the imbalance of free radical metabolism (Xu et al., 2023)

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Neuroscience 566, 1727

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Regarding DUX4 targets, ROS seem to have an important role in alleviating the effects of DUX4 toxicity in the disease mechanism, whilst current research has linked the main driver of apoptosis to cellular hypoxia response [179]

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