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[1] However, because B12 is water-soluble, the body typically eliminates excess amounts through renal excretion without adverse effects

During the development of osteoarthritis, the synovium undergoes interstitial vascularization, fibrosis and hyperplasia (167), and macrophages and fibroblasts in the synovium can release proinflammatory cytokines, etc., which cause synovitis and cartilage degeneration

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