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In 1997, Lee published a groundbreaking paper in the New England Journal of Medicine showing that acetaminophen was the leading cause of acute liver failure at Parkland Memorial hospital in Dallas, despite the drugs apparent overall safety. Not to be confused with chronic liver failure, such as that caused by alcoholism, acute liver failure is a sudden, often fatal condition that affects about 2,000 Americans each year

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All documented findings remain restricted to laboratory-based evaluation and analytical observation