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74 A similar finding was observed with corneal fluorescein staining, indicating increased epithelial damage of the cornea in patients with dry eye due to SARDs

Ethics declarations Ethics approval and consent to participate All animal studies were conducted with permission from the Ethics Committee of the Xinhua Hospital (Shanghai Jiao Tong University, School of Medicine, No

Methods Animals Thirty female SpragueDawley rats weighing 200 10 g were purchased from the Chinese Academy of Medical Sciences (Shanghai, China)

Behaviorally, the LAC treatment during the last part of chronic restraint stress (CRS) enhanced resilience and reversed the effect of CRS, which is shown by increased social interaction and reduced passive behavior in a forced swim test ( Disorders of metabotropic glutamate (mGlu) receptors and neurotrophins have significant negative effects on neuroplasticity, leading to depression, but LAC regulate brain type 2 metabotropic glutamate (mGlu2) receptors and N-methyl-D-aspartic acid (NMDA) receptors to induce antidepressant effect ( Neurotrophic factors are associated with the pathogenesis of depression (9395)

doi: 10.1016/S2215-0366(22)00260-7

doi: 10.2174/1872213X13666190426164124 10 NaeemAMingYHuP-YJieKYaliLZhangHet al