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2.5 Quality assessment and risk of bias In line with PRISMA guidelines, the assessment of methodological quality was conducted to evaluate the strength of evidence, recognising that methodological limitations may introduce bias

First aid kit and oxygen balloon

Thinner individuals may require shorter needles, while those with more muscle or adipose tissue may need longer ones to reach the muscle layer effectively

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This is attributed to the heightened levels of NNMT potentially rendering NAM irretrievable, thereby constraining NAD + -dependent processes (Trammell and Brenner, 2015)