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Betulin (BE) is a triterpenoid compound in the bark of Betula platyphylla Sukaczev [214], which can overcome gefitinib resistance in EGFR wild-type /KRAS mutant NSCLC cells by inducing ferrodeath when used in combination with gefitinib [215]

J Pharm Res 7:828835 [Google Scholar] Singh PP, Chandra A, Mahdi F, Ray A, Sharma P (2010a) Reconvene and reconnect the antioxidant hypothesis in human health and disease

doi: 10.1016/0047-6374(87)90071-6 [DOI] [PubMed] [Google Scholar] 12.Halliday G.M.2005

Pain is typically the main symptom, but other symptoms may include depression, anxiety, sleep disorders, and various other conditions

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Consequently, GA may be mitigate adipose tissue inflammation by suppressing the expression of inflammatory mediators, either within the white adipose tissue or in macrophages (Tanaka et al., 2020b)
