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Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC 157 in rat and mouse

Intramuscular hydroxocobalamin injections are the recommended first-line treatment in the UK, as they bypass the absorption problem caused by lack of intrinsic factor

What exists in the scientific literature

Initially frequent, then usually once every 13 months for maintenance

Pancreatic insufficiency can make it hard for B12 to be released from food proteins

Targeted Nutrient Delivery: The injection is administered intramuscularlyusually in the upper arm or hipfor rapid absorption and maximum effectiveness