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10.1242/dev.166074 Development (Cambridge) 129 QianX.SuY.AdamC

Purified ferritin from glioblastoma-derived cell line has marked apoptosis-stimulating activity and are inhibited by neutralizing anti-ferritin antibody Ab rH02, however, isoferrin released from cultured neonatal astrocytes did not show this activity, suggesting that the transition of astrocytes to a malignant phenotype is accompanied by alterations in iron metabolic processes (26)

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For high-resolution HPLCMS runs, data collection was done via MassHunter Workstation Software (B.08.00) and data analysis relied on MassHunter Workstation Software Qualitative Analysis (10.0)

Increases in genes associated with cytokine pathways, antigen presentation, the complement cascade, and reactivity [e.g., glial fibrillary acidic protein ( Gfap )] were observed in astrocytes in the hippocampus, hypothalamus, visual cortex, striatum and cerebellum of aged mice (24-months-old