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2.3.1 Iron-based nanoparticles A variety of iron-based nanoparticles have been shown to reedit M2 TAMs to M1 TAMs, such as iron in superparamagnetic iron oxide nanoparticles (SPION) that can induce the transformation of human monocytic leukemia cell (THP1)-derived M2 macrophages to a high CD86+, tumor necrosis factor- (TNF-) positive M1 macrophage subtype (32)

Veterinary Consultation: Always consult your veterinarian before starting any new supplement, particularly for pets with existing eye conditions or those on other medications