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Epub 2021 Sep 2

The role of S1PR2 appears highly context-dependent, potentially exerting opposing effects in different tissues or disease states ( In summary, S1PR2 adds another layer of complexity to BA signaling within the TIME, potentially acting as a receptor for conjugated BAs to influence cancer cell invasiveness and inflammation, possibly contributing to a pro-tumorigenic microenvironment in certain settings

After electrophoresis, the gel was stained with Coomassie Brilliant Blue or transblotted onto a PVDF membrane and incubated with 0.25% polyvinylpyrrolidone (Sigma, St

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10.1016/j.jad.2016.09.047

By age 40 yr, there is a ubiquitous and significant occurrence of neuropathological hallmarks of AD, as indicated by widespread deposition of senile plaques and neurofibrillary tangles, but dementia is variable