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However, human epidemiological evidence for transgenerational effects remains limited, primarily due to the extended timeframes required for multigenerational studies and the practical challenges of maintaining long-term cohorts across decades ( Low-Dose Chronic Exposure Effects Present Assessment Challenges EEDs frequently exhibit non-monotonic dose-response (NMDR) patterns, where low-dose chronic exposure may produce more pronounced biological effects than acute high-dose exposure

Caminero A, Nistal E, Herrn AR et al (2014) Gluten metabolism in humans

Impact on Bioavailability Bioavailability refers to the percentage of an active substance that reaches the systemic circulation after being administered (usually orally) and is able to produce its therapeutic effect

BPC-157, a gastric pentadecapeptide derived from proteolytic enzyme preparations, and TB-500, a synthetic analogue of thymosin beta-4, represent emerging agents with broad biological activity relevant to tissue repair and cytoprotection

doi:10.1186/s41043-024-00528-0 Li W, Liu S, Meng X, Liu H

Surgery (2016) 160(5):136775.10.1016/j.surg.2016.05.035 44 CanzianiMFrattiniFCavalliMAgrustiSSomalvicoFCampanelliG