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Of them, BI1701963, an orally bioavailable pan-KRAS inhibitor, has entered a phase I clinical trial (NCT04111458), which has an obvious effect in inducing tumour senescence

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In this study, after adding MHY, the p-mTOR protein level that was reduced during combined CAR/DPP treatment was restored and the increased autophagy levels were reduced accordingly

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Mukherjee, P

Thus, the AsA-GSH pathway in chloroplast is imperative in protecting it from the deleterious effects of excess ROS production