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Early Decline in Glucose Transport and Metabolism Precedes Shift to Ketogenic System in Female Aging and Alzheimers Mouse Brain: Implication for Bioenergetic Intervention

Given that flexibility of the membrane distal D1 and D2 domains of LepR appeared to limit the resolution of these reconstructions, we next purified and performed cryo-EM analysis on a truncated leptinLepR D3 D7 -zip complex, which yielded an improved 4.5 resolution 3D reconstruction (Fig

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3, 47 However, further controlled randomized trials are necessary to establish the efficacy of these therapeutic agents

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