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Description
Grand Island, NY, USA)] over 10 days to promote differentiation of 3T3-L1 fibroblasts into adipocytes
NNMT inhibitors reduced intracellular 1-MNA, increased intracellular NAD + and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis in adipocytes
When NNMT is blocked, these fat cells shift toward a more metabolically active phenotype
5-Amino-1MQ (5-amino-1-methylquinolinium) is a selective inhibitor of NNMT nicotinamide N-methyltransferase
Kannt, A
It is a research compound with preclinical data only -- no human clinical trials have been published
