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Increased inhibitory neurotransmission, glutamatergic/GABAergic E/I imbalance, and chronic stress-related emotional dysfunction reduce PFC activity

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IGF-1 exerts its biological effect through binding to the IGF1 receptor (IGF1R), its effect is modulated through interaction with a group of binding proteins (IGFBPs), which tend to inhibit the effect of IGF-1 [2]

The serum in each group was blended into working solution and supplemented with peroxide reagent

This dynamic interplay enables the cell to regulate the ATP supply from the mitochondria according to its energy demands [71]

Kornblau SM, Konopleva M, Andreeff M