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Thus, once MTHFR has reduced 5,10-methyleneTHF to 5-MTHF, the Vitamin B12 dependent methionine synthase, encoded by MTR, uses this reduced folate to convert Hcy back into methionine

30 , E21 (2002)

doi: 10.1021/acs.molpharmaceut.3c00173 119 Bhargava-ShahAFoygelKDevulapallyRPaulmuruganR

Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection