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Additionally, HDAC6 inhibitors activate redox-regulating proteins like peroxiredoxins (reduce ROS) and support the function of the autophagy and ubiquitin-proteasome system (UPS) (both are impaired in PD patients) 62

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Meanwhile, we must also take into account that the amino - acid metabolic profiles we observed are likely to be affected by a multitude of factors, such as genetic predispositions, environmental exposures, and dietary habits

Probiotics counteract this effect by generating SCFAs such as butyrate and propionate, which are HDAC inhibitors

[6] Porpora MG, Brunelli R, Costa G, Imperiale L, Krasnowska EK, Lundeberg T, Nofroni I, Piccioni MG, Pittaluga E, Ticino A, Parasassi T