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Chung Sim Lim from the Canadian Medical Association Journal does note that stockings are generally safe to use, with relatively few complications; poorly fitting stockings can cause discomfort and, at worst, pressure necrosis, so be sure to get properly fitted socks to avoid any additional and unintentional feet and ankle discomfort

Studies have examined their effects on wound healing in diabetic patients, collagen synthesis in human skin, hair follicle enlargement and gene expression in skin cells