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Vitamin D levels are prognostic factors for connective tissue disease associated interstitial lung disease (CTD-ILD)

It is a known antioxidant and detoxifies xenobiotics (chemical substances foreign to living beings)

Of more than 100 compounds synthesized and tested for TGR inhibition (a more thorough description of compound design will form the basis of a future manuscript), the most promising were selected to be extensively characterized in the in vitro and in vivo studies described below

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Then, L-theanine alone or in combination with theobromine could effectively inhibit tumor production in male Wistar rats with colon cancer induced by dimethylhydrazine, and the mechanism of action was related to downregulating the Akt/mTOR (mammalian target of rapamycin) and JAK2/STAT3 pathways and increasing the mRNA and protein expression of tumor suppressor Smad2 (73)

Similar results were achieved by Schauer and colleagues, in a model of warm ischemia, followed by isolated rat liver perfusion [221]