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Under normal circumstances, O-GlcNAcylation functions as a sensor for nutrient availability and cellular stress, modulating the stability, distribution, and activity of many proteins within the nucleus and cytoplasm [91]

Oncoscience 3:135142 Lima M, Aloizou AM, Siokas V, Bakirtzis C, Liampas I, Tsouris Z, Bogdanos DP, Baloyannis SJ, Dardiotis E (2022) Coronaviruses and their relationship with multiple sclerosis: is the prevalence of multiple sclerosis going to increase after the Covid-19 pandemia

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Disease states that increase shear stress in the endothelium could lead to increased expression of -globin through the activation of KLF2 and/or KLF4 and, consequently, contribute to the dysregulation of NO signaling by increasing -globin

These aldehydes also activate immune responses by functioning as DAMPs, stimulating dendritic cells and inducing pro-inflammatory cytokines such as IL-6, IL-1, and TNF-, contributing to vitiligos autoimmune component [87]

Specialized services, such as art therapy and EMDR, are available to help clients process and overcome their trauma