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However, pathological modifications oxidation, glycation, citrullination, carbonylation, and enzymatic carboxyethylation of cysteine (linked to ankylosing spondylitis) can render self-proteins immunogenic, driving autoimmune disease by presenting chemically altered peptides to the immune system as foreign antigens.

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Although LGIT is not as high in fat as the ketogenic diet, it still includes moderate amounts of healthy fats and protein to provide sustained energy and satiety

Additional benefits that have been associated with the nutrients in bone broth include decreased anxiety, improved sleep quality, better eye health, detoxification support, and faster muscle repair and growth

However, it should be noted that supplementation of betaine in individuals with CBS deficiency, without sufficient dietary methionine restriction, leads to methionine excess with severe clinical consequences (Schwahn et al, 2019)

High index of suspicion should be present among physicians when a vegetarian patient presents with hyperpigmentation over the body