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Early-phase studies showed that CB-839 is safe and well-tolerated in solid tumors with promising signs of clinical activity in multiple tumor types including triple-negative breast cancer, NSCLC, and mesothelioma

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Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice

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In the previous study, histone Klac has been suggested to promote tumor development through promoting the immunosuppressive role of tumor-infiltrating myeloid cells or driving TAMs polarization to an M2-like phenotype

Due to the essential dependence of viruses on the metabolic networks of their host for reproduction 11 , the utilization of in silico models of virally infected cells provides new avenues to identify druggable targets for antiviral therapy 12