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AMP-activated Protein Kinase Deficiency Rescues Paraquat-Induced Cardiac Contractile Dysfunction through an Autophagy-dependent Mechanism

Furthermore, another component of the API complex, FOSL1, is highly expressed in IPSC-derived motor neurons from SOD1 patients carrying the E100G mutation (Bhinge et al., 2017) compared to isogenic controls, suggesting that the AP1 complex is a driver for neurodegeneration
2014 Mar 19;15(3):4837-55

Translated to a 70 kg human using allometric scaling, that yields approximately 250 to 500 mcg per day

Moreover, compounds 5g and 5e induced apoptosis in CRC cell lines and induced caspase activation
