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Author contributions HH: Conceptualization, Methodology, Writingoriginal draft, Writingreview and editing

PMID: 11568695 Vaccaro A.R.., Klein, G.R, Thaller, J

[DOI] [PubMed] [Google Scholar] 5.Meister A

Published Phase 2 trial data (NEJM, 2023) demonstrated substantial reductions in body weight in some participants exceeding 20% over approximately 48 weeks making retatrutide one of the most potent agents currently in development for obesity and metabolic disease

In addition to these mechanisms, oxidative stress activates multiple MAPK pathways, including p38 MAPK, JNK, and ERK1/2

The metabolism of Hcy is crucial for the provision of methyl groups, which are indispensable for various biological functions [13]