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When the intracellular GSH levels were measured (in a synthetic medium in the absence of inhibitors), the recombinants had a threefold ( GSH1 ) and a sixfold ( LmgshF, StgshF , gsh2 LmgshF ) higher level compared to the reference strain while the ethanol levels did not increase proportionately

470 Additionally, the hepatic microRNA-34a, which is increased in obesity, reduces NAD + levels and SIRT1 activity by targeting NAMPT

SLC7A11 inhibition results in GSH depletion, which downregulates GPX4 levels, thereby promoting cellular/subcellular membrane damage caused by LPOs [28]

Shad Hassan: Data analysis and interpretation, writingoriginal draft