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The net effect, of TKT deficiency in hepatocytes, is enhanced mitochondrial DNA content, increased ATP production, and overall mitochondrial activity

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There are three main types of medical therapy, including somatostatin receptor ligands (SRL), GHR antagonists and dopamine agonizts 42,43 (Table 1)

Most molecules belong to one or the other

In senescent cells, FOXO4 sequesters p53 in the nucleus, preventing it from triggering apoptosis