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This allele codes for an ALDH2 enzyme with little activity leading to high AA concentrations after the consumption of even small amounts of alcohol

The incidence of dementia among DS patients is 10% in the age range 3550 yr and 55% in the age range 5060 yr and becomes 75% above the age of 60 yr, but AD neuropathology is present in virtually all adults with DS older than 40 yr (460)

[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Khoshbaten M., Aliasgarzadeh A., Masnadi K., Tarzamani M.K., Farhang S., Babaei H., Kiani J., Zaare M., Najafipoor F

have identified a group of genes that are upregulated in various tumor types in African American cancer patients compared to European American patients 3

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Accompanied by direct glutathionylation of GAPDH in glycolysis, glucose metabolism was altered by vitamin C treatment