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In melanoma, LPO products can exert both pro- and anti-tumorigenic effects depending on their concentration, cellular context, and tumor stage [108]
May 31 2019;55(6)doi:10.3390/medicina55060233
L., Zhang B
SzebnyiKFrediABajtaiESamaSCsiszarAGombosBet alEffective targeting of breast cancer by the inhibition of P-glycoprotein mediated removal of toxic lipid peroxidation byproducts from drug tolerant persister cells
10.1073/pnas.1521318113 Proc
Among these, -glutamylcysteine triggered the strongest response, though the corresponding concentrations (2000M) are 200-fold above the reported intracellular concentrations (5-10M, (Mrtensson, 1987))
