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Inflammatory cytokines, such as tumor necrosis factor alpha (TNF) and interleukin6 (IL6), have been shown to impair insulin signaling and glucose uptake in muscle and adipose tissue and to promote hepatic gluconeogenesis and lipolysis

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Identifies induction of pluripotency genes [Sox2, Oct4 (Pou5f1), Nanog] as a mechanism by which hypertrophic chondrocytes transdifferentiate into bone-forming osteoblasts during endochondral ossification

[DOI] [PubMed] [Google Scholar] Mangold J.B., Abdel-Monem M.M

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However, swelling can occasionally be more serious or last longer