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In contrast, substances transported mainly via the trigeminal pathway take longer to reach the brain, indicating that they are more likely to be transported transcellularly [47]

Even when ingested in normal amounts, copper and iron may become toxic in certain individuals with genetic predispositions that lead to hepatic overload - iron overload in hemochromatosis [11-17] or copper overload in Wilson disease [18-27]

Borthakur G , Jabbour E, Wang X, Cortes J, Ravandi F, Kadia T, Bass J, Brandt M, Kantarjian H

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Magnesium lithospermate B ameliorates diabetic nephropathy by suppressing the uremic toxin formation mediated by gut microbiota
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