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The importance of identifying PsO patients at elevated risk of progressing to PsA arises from the observed disparity in treatment efficacy vs cutaneous signs, wherein fewer than 50% of patients achieve clinical remission once PsA has been established.4 These circumstances drive research into the feasibility of preventing PsA development or intercepting its progression.5 Given the established correlation between PsO severity and PsA risk,3 several investigations have explored the prospect of aggressive systemic therapies, such as biologic therapies, as potential preventive measures vs PsA development.1,613 In the current landscape, biologic therapies represent some of the most effective therapies for PsO

Bhattacharya, A., Chowdhury, A., Chaudhury, K

Nature 407, 538541, 10.1038/35035131 (2000)

Biopsies from ulcer edge yield higher histological activity scores than biopsies from non-ulcerated mucosa in active ulcerative colitis

They enter the cell, reach the nucleus, and interact with chromatin, the complex of DNA and histone proteins that determines which genes are accessible for transcription

The relation between sexual orientation and penile size